Mir-17/92-klustret: en omfattande uppdatering av dess genomik

Hong Zhang - Institutionen för medicinska vetenskaper

The miR-17/92 cluster is among the best-studied microRNA clusters. Interest in the cluster and its members has been increasing steadily and the number of publications has grown exponentially since MiR-17-92 cluster is an oncogenic miRNA cluster that is implicated in several cancers, although its role in hepatocarcinogenesis has not been clearly defined. miR-17-92 is an oncogenic miRNA cluster implicated in the development of several cancers; however, it remains unknown whether the miR-17-92 cluster is able to regulate cholangiocarcinogenesis. This study was designed to investigate the biological functions and molecular mechanisms of the miR-17-92 cluster in cholangiocarcinoma.

Mirna 17-92 cluster

The miR-17-92 cluster is also crucial in the development of B-NHL. Tagawa et al documented that c-Myc can not only promote the transcription of miR-17-92 cluster, but can also act as a target of the miR-17-92 cluster. A high-level of miR-17-92 cluster expression also results in the poor survival rate of patients with MCL . Interestingly, deletion or overexpression of miR-17- 92 cluster in keratinocytes, or deletion of miR-17-92 in T cells did not significantly affect IMQ-induced psoriasis- like dermatitis develop-ment in the mutant mice compared with wild-type littermates.

1A). miRNA-17–92 cluster plays a role in Y79 cell proliferation. Invasion— A matrigel invasion assay was performed on the Y79 cells after 48 h of treatment with antagomirs.

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Thus, miRNA miR-17- 92 cluster The miR-17-92 cluster is also crucial in the development of B-NHL. Tagawa et al documented that c-Myc can not only promote the transcription of miR-17-92 cluster, but can also act as a target of the miR-17-92 cluster.

Mikrorna-17-92-klustret främjar proliferationen och - byvdev.com

The functional analysis of miR-17-92 is intricate by the existence of two paralogues: miR-106a-363 and miR-106b-25. This miRNA dose-dependent target selection was also confirmed in other target genes, including CCND1, CDKN1 and E2F1. After overexpressing let-7a-7f or the miR-17-92 clusters at wide-ranging doses, the target genes displayed a nonlinear correlation to the transfected miRNA. Dysregulated miRNA expression is observed in PKD, but whether miRNAs are directly involved in kidney cyst formation and growth is not known. Here,we show that miR-17~92, an oncogenic miRNA cluster, is up-regulated in mouse models of PKD. Kidney-specific transgenic overexpression of miR-17~92 produces kidney cysts in mice.

Usually, miRNA clusters consist of two or three miRNAs, but larger clusters also exist, for example, the miR-17-92 cluster is found on human chromosome 13 and is composed of six miRNAs.
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Recent research identifies the miR-17-92 cluster as a crucial player in the development of the immune system, the heart, the lung, and oncogenic events. The miR-17-92 gene cluster, a polycistron encoding six microRNAs (miRNA), is frequ … In mammalian cells, activation of oncogenes usually triggers innate tumor-suppressing defense mechanisms, including apoptosis and senescence, which are compromised by additional mutations before cancers are developed. 3.

Crossref Medline Google Scholar; 16. Zhang Y, Ueno Y, Liu XS, Buller B, Wang X, Chopp M, et al.. The MicroRNA-17-92 cluster enhances axonal outgrowth in embryonic cortical The miR-17-92 cluster was among the first miRs that were linked to tumor angiogenesis. The miR-17-92 cluster is a typical example of a polycistronic miR cluster encoding the miRs miR-17, miR-18a, miR-19a/b, miR-20a, and miR-92a, which are highly expressed in several tumors.
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After overexpressing let-7a-7f or the miR-17-92 clusters at wide-ranging doses, the target genes displayed a nonlinear correlation to the transfected miRNA. Dysregulated miRNA expression is observed in PKD, but whether miRNAs are directly involved in kidney cyst formation and growth is not known.

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The MicroRNA-17-92 cluster enhances axonal outgrowth in embryonic cortical 2005-11-01 2019-10-03 2015-08-01 2011-11-25 As discussed, the mir-17-92 cluster has been proposed to have a functional relationship with Patched signalling. An abnormal functioning of which can induce the GNP tumours typical of Medullablastoma. This hypothesis was arrived at by taking miRNA expression profiles of … Because of its strong oncogenic activity, the miR-17-92 cluster was also named as oncomiR-1. Thus, here we asked whether the placement of miRNAs in an miRNA cluster contributes to determining the miRNA expression patterns by investigating the relationship between expression and placement of miRNAs in the miR-17-92 cluster. 2007-02-01 Usually, miRNA clusters consist of two or three miRNAs, but larger clusters also exist, for example, the miR-17-92 cluster is found on human chromosome 13 and is composed of six miRNAs. miRNA The miRNA-17-92 cluster is also predicted to provide important supplementary tools for tumor classification, determination of the treatment plan and analysis of prognosis by clinicians. For example, the use of miR-17 antagonists represents a novel therapeutic approach to the treatment of chronic lymphocytic leukemia .